Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
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چکیده
منابع مشابه
Two different “tales” of ATG7: Clinical relevance to myelodysplastic syndromes
Somatic mutations in U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) are associated with various cancers including myelodysplastic syndrome (MDS). Mutant U2AF1 promotes malignant transformation by inhibiting autophagy, partly as a result of alterations in the 3' tail of ATG7. This results in altered mitochondrial function, increased reactive oxygen species production, and genomic instability.
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ژورنال
عنوان ژورنال: Molecular & Cellular Oncology
سال: 2016
ISSN: 2372-3556
DOI: 10.1080/23723556.2016.1212686